概述

  • 产品名称Anti-FGF2抗体
    参阅全部 FGF2 一抗
  • 描述
    兔多克隆抗体to FGF2
  • 经测试应用适用于: Neutralising, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment corresponding to Human FGF basic aa 58-210.
    Database link: P09038

性能

应用

Our Abpromise guarantee covers the use of ab11937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Neutralising Use a concentration of 3.5 µg/ml.

Use at a concentration of 3.5 µg/ml to yield one-half maximal inhibition [ND50] of the biological activity of human FGF basic (FGF2) (5ng/ml) on HUVEC cells.

WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 30 kDa.

靶标

  • 功能Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:23469107).
  • 组织特异性Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
  • 序列相似性Belongs to the heparin-binding growth factors family.
  • 翻译后修饰Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
    Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
  • 细胞定位Secreted. Nucleus. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Basic fibroblast growth factor antibody
    • Basic fibroblast growth factor bFGF antibody
    • BFGF antibody
    • FGF 2 antibody
    • FGF B antibody
    • FGF-2 antibody
    • Fgf2 antibody
    • FGF2 basic antibody
    • FGF2_HUMAN antibody
    • FGFB antibody
    • Fibroblast growth factor 2 (basic) antibody
    • Fibroblast growth factor 2 antibody
    • Fibroblast growth factor, basic antibody
    • HBGF 2 antibody
    • HBGF-2 antibody
    • HBGF2 antibody
    • HBGH 2 antibody
    • HBGH2 antibody
    • Heparin binding growth factor 2 precursor antibody
    • Heparin-binding growth factor 2 antibody
    • Prostatropin antibody
    see all

Anti-FGF2 antibody 图像

  • All lanes : Anti-FGF2 antibody (ab11937)

    Lane 1 : Recombinant fragment human FGF basic
    Lane 2 : Recombinant fragment mouse FGF basic
    Lane 3 : Recombinant fragment rat FGF basic


    Predicted band size : 30 kDa

Anti-FGF2 antibody (ab11937)参考文献

ab11937 has not yet been referenced specifically in any publications.

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