概述

  • 产品名称Anti-FGF2抗体[0.T.50]
    参阅全部 FGF2 一抗
  • 描述
    小鼠单克隆抗体[0.T.50] to FGF2
  • 特异性ab33103 recognizes the native, non denatured form of basic FGF. It does not recognise acidic FGF (HBGF 1).
  • 经测试应用适用于: Neutralisingmore details
    不适用于: WB
  • 种属反应性
    与反应: Mouse, Rat, Cow, Human
  • 免疫原

    Full length native protein: Purified bovine brain basic FGF (HBGF-2).

性能

应用

Our Abpromise guarantee covers the use of ab33103 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Neutralising Use a concentration of 2.5 µg/ml.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:23469107).
    • 组织特异性Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
    • 序列相似性Belongs to the heparin-binding growth factors family.
    • 翻译后修饰Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
      Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
    • 细胞定位Secreted. Nucleus. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Basic fibroblast growth factor antibody
      • Basic fibroblast growth factor bFGF antibody
      • BFGF antibody
      • FGF 2 antibody
      • FGF B antibody
      • FGF-2 antibody
      • Fgf2 antibody
      • FGF2 basic antibody
      • FGF2_HUMAN antibody
      • FGFB antibody
      • Fibroblast growth factor 2 (basic) antibody
      • Fibroblast growth factor 2 antibody
      • Fibroblast growth factor, basic antibody
      • HBGF 2 antibody
      • HBGF-2 antibody
      • HBGF2 antibody
      • HBGH 2 antibody
      • HBGH2 antibody
      • Heparin binding growth factor 2 precursor antibody
      • Heparin-binding growth factor 2 antibody
      • Prostatropin antibody
      see all

    Anti-FGF2 antibody [0.T.50] (ab33103)参考文献

    This product has been referenced in:
    • Kujawski M  et al. Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J Clin Invest 118:3367-77 (2008). Neutralising ; Human . Read more (PubMed: 18776941) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"