Anti-FGF19抗体(ab225942)
Key features and details
- Rabbit polyclonal to FGF19
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-FGF19抗体
参阅全部 FGF19 一抗 -
描述
兔多克隆抗体to FGF19 -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Recombinant full length protein corresponding to Human FGF19 aa 1 to the C-terminus.
Database link: O95750 -
阳性对照
- WB: Mouse brain lysate. IHC-P: Human small intestine tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab225942于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P | (4) |
1/20 - 1/200.
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WB |
1/1000 - 1/5000. Detects a band of approximately 24 kDa (predicted molecular weight: 24 kDa).
|
说明 |
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IHC-P
1/20 - 1/200. |
WB
1/1000 - 1/5000. Detects a band of approximately 24 kDa (predicted molecular weight: 24 kDa). |
靶标
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功能
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB. -
组织特异性
Expressed in fetal brain, cartilage, retina, and adult gall bladder. -
序列相似性
Belongs to the heparin-binding growth factors family. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 9965 Human
- NCBI: NM_005117 Human
- Omim: 603891 Human
- SwissProt: O95750 Human
- Unigene: 249200 Human
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别名
- FGF 19 antibody
- FGF-19 antibody
- FGF15 antibody
see all
图片
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Anti-FGF19 antibody (ab225942) at 1/1000 dilution + Mouse brain lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 24 kDa
Observed band size: 24 kDa -
Paraffin-embedded human small intestine tissue stained for FGF19 with ab225942 at 1/100 dilution in immunohistochemical analysis.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab225942 被引用在 3 文献中.
- Chen J et al. Enhanced expression of FGF19 predicts poor prognosis in patients with non-small cell lung cancer. J Thorac Dis 13:1769-1784 (2021). PubMed: 33841967
- Zhou Y et al. MicroRNA-9-3p Aggravates Cerebral Ischemia/Reperfusion Injury by Targeting Fibroblast Growth Factor 19 (FGF19) to Inactivate GSK-3ß/Nrf2/ARE Signaling. Neuropsychiatr Dis Treat 17:1989-2002 (2021). PubMed: 34177264
- Dolezelova E et al. High soluble endoglin levels regulate cholesterol homeostasis and bile acids turnover in the liver of transgenic mice. Life Sci 232:116643 (2019). PubMed: 31299237