概述

  • 产品名称
  • 描述
    兔多克隆抗体to FGD1
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide, corresponding to a region within N terminal amino acids 2-51 (HGHRAPGGAG PSEPEHPATN PPGAAPPACA DSDPGASEPG LLARRGSGSA) of Human FGD1 (NP_004454).

  • 阳性对照
    • Transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab104789 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 107 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
  • 组织特异性
    Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
  • 疾病相关
    Aarskog-Scott syndrome
    Defects in FGD1 are found in a patient with non-syndromal X-linked mental retardation.
  • 序列相似性
    Contains 1 DH (DBL-homology) domain.
    Contains 1 FYVE-type zinc finger.
    Contains 2 PH domains.
  • 结构域
    The DH domain is involved in interaction with CCPG1.
  • 细胞定位
    Cytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Associated with membrane ruffles and lamellipodia.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AAS antibody
    • Faciogenital dysplasia 1 protein antibody
    • FGD1 antibody
    • FGD1_HUMAN antibody
    • FGDY antibody
    • FYVE RhoGEF and PH domain containing protein 1 antibody
    • FYVE, RhoGEF and PH domain-containing protein 1 antibody
    • Rho/Rac GEF antibody
    • Rho/Rac guanine nucleotide exchange factor FGD1 antibody
    • ZFYVE3 antibody
    • Zinc finger FYVE domain containing protein 3 antibody
    • Zinc finger FYVE domain-containing protein 3 antibody
    see all

图片

  • Anti-FGD1 antibody (ab104789) at 1 µg/ml + Transfected 293T cell lysate at 10 µg

    Predicted band size : 107 kDa

实验方案

文献

ab104789 has not yet been referenced specifically in any publications.

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