概述

  • 产品名称Anti-fetal hemoglobin抗体
    参阅全部 fetal hemoglobin 一抗
  • 描述
    羊多克隆抗体to fetal hemoglobin
  • 特异性By immunoelectrophoresis and ELISA this antibody reacts specifically with human hemoglobin F. No antibody was detected against hemoglobin A1, A2, S or human serum proteins.
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Human Hemoglobin F

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明The antibody was isolated by affinity chromato-graphy using antigen coupled to agarose beads. Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab19364 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
IHC-P 1/20. Antigen retrieval is not essential but may optimise staining. PubMed: 21378008

靶标

  • 相关性The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'
  • 细胞定位Cytoplasmic
  • 数据库链接
  • 别名
    • A gamma globin antibody
    • G gamma globin antibody
    • Gamma 1 globin antibody
    • Gamma 2 globin antibody
    • Gamma A hemoglobin antibody
    • Gamma globin antibody
    • Hb F Agamma antibody
    • Hb F Ggamma antibody
    • hbfagamma antibody
    • hbfggamma antibody
    • HBG 1 antibody
    • HBG 2 antibody
    • HBG1 antibody
    • HBG2 antibody
    • HBGA antibody
    • HBGR antibody
    • Hemoglobin gamma 1 chain antibody
    • Hemoglobin gamma 2 chain antibody
    • Hemoglobin gamma A antibody
    • Hemoglobin gamma A chain antibody
    • Hemoglobin gamma G antibody
    • Hemoglobin gamma G chain antibody
    • Hemoglobin gamma regulator of antibody
    • Hemoglobin subunit gamma 1 antibody
    • Hemoglobin subunit gamma 2 antibody
    • HSGGL 1 antibody
    • HSGGL1 antibody
    • Methemoglobin antibody
    • PRO 2979 antibody
    • PRO2979 antibody
    see all

Anti-fetal hemoglobin antibody (ab19364)参考文献

This product has been referenced in:
  • Wolk M & Martin JE Fetal haemopoiesis marking low-grade urinary bladder cancer. Br J Cancer 107:477-81 (2012). Read more (PubMed: 22735903) »
  • Wolk M & Martin JE Fetal haemoglobin (HbF) as an immunohistochemical tumour marker in bone marrow and spleen. J Clin Pathol 64:645-7 (2011). IHC-P ; Human . Read more (PubMed: 21378008) »

See all 4 Publications for this product

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