RabMAb

Anti-Ferritin Light Chain抗体[EPR5259] (ab109019)

概述

  • 产品名称Anti-Ferritin Light Chain抗体[EPR5259]
    参阅全部 Ferritin Light Chain 一抗
  • 描述
    兔单克隆抗体[EPR5259] to Ferritin Light Chain
  • 经测试应用适用于: WB, IP, ICCmore details
    不适用于: Flow Cyt or IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to residues near the N-terminus of Human Ferritin Light Chain.

  • 阳性对照
    • Human fetal liver, HepG2 and HeLa cell lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

应用

Our Abpromise guarantee covers the use of ab109019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 20 kDa.
IP 1/10 - 1/100.
ICC 1/100 - 1/250.
  • 应用说明Is unsuitable for Flow Cyt or IHC-P.
  • 靶标

    • 功能Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
    • 疾病相关Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.
      Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
    • 序列相似性Belongs to the ferritin family.
      Contains 1 ferritin-like diiron domain.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Ferritin L chain antibody
      • Ferritin L subunit antibody
      • Ferritin light chain antibody
      • Ferritin light polypeptide antibody
      • ferritin light polypeptide like 3 antibody
      • FRIL_HUMAN antibody
      • FTL antibody
      • LFTD antibody
      • NBIA 3 antibody
      • NBIA3 antibody
      see all

    Anti-Ferritin Light Chain antibody [EPR5259] 图像

    • All lanes : Anti-Ferritin Light Chain antibody [EPR5259] (ab109019) at 1/1000 dilution

      Lane 1 : Human fetal liver lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : HeLa cells lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 20 kDa

    Anti-Ferritin Light Chain antibody [EPR5259] (ab109019)参考文献

    This product has been referenced in:
    • Wu T  et al. Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PLoS One 11:e0149361 (2016). WB, IHC, ICC/IF ; Human . Read more (PubMed: 26871431) »

    See 1 Publication for this product

    Product Wall

    Application Western blot
    Sample Mouse Tissue lysate - whole (Liver)
    Gel Running Conditions Reduced Denaturing (4-20%)
    Loading amount 50 µg
    Specification Liver
    Blocking step Rockland fluorescent blocking buffer as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 50% · Temperature: 25°C
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    提交于 Jul 07 2015

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"