Anti-Ferritin Light Chain抗体[AF7B7] (ab80617)

概述

  • 产品名称Anti-Ferritin Light Chain抗体[AF7B7]
    参阅全部 Ferritin Light Chain 一抗
  • 描述
    小鼠单克隆抗体[AF7B7] to Ferritin Light Chain
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    His-tagged recombinant Human Ferritin Light Chain, expressed in E. Coli

  • 阳性对照
    • HeLa cells lysate.

性能

应用

Our Abpromise guarantee covers the use of ab80617 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/5000. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa).

靶标

  • 功能Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
  • 疾病相关Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.
    Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
  • 序列相似性Belongs to the ferritin family.
    Contains 1 ferritin-like diiron domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ferritin L chain antibody
    • Ferritin L subunit antibody
    • Ferritin light chain antibody
    • Ferritin light polypeptide antibody
    • ferritin light polypeptide like 3 antibody
    • FRIL_HUMAN antibody
    • FTL antibody
    • LFTD antibody
    • NBIA 3 antibody
    • NBIA3 antibody
    see all

Anti-Ferritin Light Chain antibody [AF7B7] 图像

  • All lanes : Anti-Ferritin Light Chain antibody [AF7B7] (ab80617) at 1/5000 dilution

    Lane 1 : HeLa cell lysate
    Lane 2 : A431 cell lysate
    Lane 3 : HepG2 cell lysate
    Lane 4 : U937 cell lysate
    Lane 5 : Hep3B cell lysate
    Lane 6 : Jurkat cell lysate
    Lane 7 : HL60 cell lysate


    Predicted band size : 20 kDa
    Observed band size : 20 kDa

Anti-Ferritin Light Chain antibody [AF7B7] (ab80617)参考文献

ab80617 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab80617.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"