概述

描述

  • 性质
    Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab6098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式
    Liquid
  • 补充说明

    Stable for one year.

    F1A alpha, also termed FEM1 beta, is a novel protein that associates with the intracellular domains of Fas and TNFR1. Over expression of F1A alpha induces apoptosis. F1A alpha also associates with CED-4 and its mammalian homologue Apaf-1, and can be cleaved by CED-3 and caspases.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • F1A alpha
    • F1A-alpha
    • F1AA
    • Fem-1-like death receptor-binding protein alpha
    • Fem-1-like in apoptotic pathway protein alpha
    • Fem1 homolog b
    • FEM1 like death receptor binding protein
    • FEM1-beta
    • FEM1b
    • FEM1B_HUMAN
    • Protein fem-1 homolog B
    see all
  • 功能
    Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
  • 组织特异性
    Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Belongs to the fem-1 family.
    Contains 8 ANK repeats.
    Contains 1 TPR repeat.
  • 细胞定位
    Cytoplasm. Nucleus. In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.
  • Information by UniProt

FEM 1B peptide (ab6098)参考文献

ab6098 has not yet been referenced specifically in any publications.

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