概述

  • 产品名称Anti-FECH抗体
    参阅全部 FECH 一抗
  • 描述
    小鼠多克隆抗体to FECH
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human FECH protein (NP_000131.2, amino acids 1-423).

  • 阳性对照
    • Human liver tissue lysate. FECH transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab88838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 48 kDa.

靶标

  • 功能Catalyzes the ferrous insertion into protoporphyrin IX.
  • 通路Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
  • 疾病相关Erythropoietic protoporphyria (EPP) [MIM:177000]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Erythropoietic protoporphyria is marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 序列相似性Belongs to the ferrochelatase family.
  • 细胞定位Mitochondrion inner membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EPP antibody
    • FCE antibody
    • Fch antibody
    • Fcl antibody
    • fech antibody
    • Ferrochelatase (protoporphyria) antibody
    • Ferrochelatase antibody
    • Ferrochelatase mitochondrial antibody
    • Heme synthase antibody
    • Heme synthetase antibody
    • HEMH_HUMAN antibody
    • mitochondrial antibody
    • Protoheme ferro lyase antibody
    • Protoheme ferro-lyase antibody
    • Protoporphyria antibody
    see all

Anti-FECH antibody 图像

  • Anti-FECH antibody (ab88838) at 1/500 dilution + human liver tissue lysate at 50 µg

    Predicted band size : 48 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-FECH antibody (ab88838) at 1/500 dilution

    Lane 1 : FECH transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 48 kDa
    Observed band size : 46 kDa (why is the actual band size different from the predicted?)

Anti-FECH antibody (ab88838)参考文献

ab88838 has not yet been referenced specifically in any publications.

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