概述

  • 产品名称Anti-FDPS抗体
    参阅全部 FDPS 一抗
  • 描述
    兔多克隆抗体to FDPS
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human FDPS aa 389-419 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).
    Database link: P14324

  • 阳性对照
    • WB: Human cytokeratin liver cell lysate, IHC-P: Human hepatocarcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab38854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 44 kDa (predicted molecular weight: 41 kDa).
IHC-P 1/10 - 1/50.

靶标

  • 功能Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
  • 通路Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
    Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
  • 序列相似性Belongs to the FPP/GGPP synthase family.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • (2E antibody
    • (2E,6E) farnesyl diphosphate synthase antibody
    • 6E)-farnesyl diphosphate synthase antibody
    • Dimethylallyltranstransferase antibody
    • Farnesyl diphosphate synthase antibody
    • Farnesyl diphosphate synthetase antibody
    • Farnesyl pyrophosphate synthase antibody
    • Farnesyl pyrophosphate synthetase antibody
    • Fdps antibody
    • FPP synthase antibody
    • FPP synthetase antibody
    • FPPS antibody
    • FPPS_HUMAN antibody
    • FPS antibody
    • Geranyltranstransferase antibody
    see all

Anti-FDPS antibody 图像

  • Anti-FDPS antibody (ab38854) + Human cytokeratin liver cell lysate

    Predicted band size : 41 kDa
    Observed band size : 44 kDa (why is the actual band size different from the predicted?)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human hepatocarcinoma tissue labelling FDPS with ab38854. A peroxidase-conjugated anti-rabbit IgG was used as the secondary antibody, followed by DAB staining.

Anti-FDPS antibody (ab38854)参考文献

This product has been referenced in:
  • Miao J  et al. Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. J Lipid Res 55:659-67 (2014). Read more (PubMed: 24516236) »
  • Souchek JJ  et al. Unbiased analysis of pancreatic cancer radiation resistance reveals cholesterol biosynthesis as a novel target for radiosensitisation. Br J Cancer 111:1139-49 (2014). Read more (PubMed: 25025965) »

See all 3 Publications for this product

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