Anti-FCRL3抗体(ab121471)

概述

  • 产品名称Anti-FCRL3抗体
    参阅全部 FCRL3 一抗
  • 描述
    兔多克隆抗体to FCRL3
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen, corresponding to amino acids 602-725 of Human FCRL3.

  • 阳性对照
    • Human cerebral cortex tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab121471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 组织特异性Primarily expressed in secondary lymphoid tissues by mature subsets of B cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B cells but also expressed in NK cells (at protein level).
  • 疾病相关Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
    Genetic variation in FCRL3 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.
  • 序列相似性Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻译后修饰Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD307c antibody
    • Fc receptor homolog 3 antibody
    • Fc receptor-like protein 3 antibody
    • FcR-like protein 3 antibody
    • FcRH3 antibody
    • FcRL3 antibody
    • FCRL3_HUMAN antibody
    • hIFGP3 antibody
    • IFGP family protein 3 antibody
    • IFGP3 antibody
    • Immune receptor translocation-associated protein 3 antibody
    • Immunoglobulin superfamily receptor translocation associated protein 3 antibody
    • IRTA3 antibody
    • SH2 domain-containing phosphatase anchor protein 2 antibody
    • SPAP2 antibody
    see all

Anti-FCRL3 antibody 图像

  • ab121471, at 1/20 dilution, staining FCRL3 in paraffin-embedded Human cerebral cortex tissue, by Immunohistochemistry.

Anti-FCRL3 antibody (ab121471)参考文献

ab121471 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam.

The product which we spoke about on the phone today is actually against the Fc region of human IgG and not against any of the Fc Receptor proteins which you inquiring about. While we do not have a single produ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"