概述

  • 产品名称Anti-FBXW10抗体
  • 描述
    兔多克隆抗体to FBXW10
  • 经测试应用适用于: ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 643-725 (LNGNCMKVLK ANGRGDPVLS FFIQGNRMVV NTESNVLMFQ FEHIKWQYAV EKTKQKKNKE KEEEKEENSL MEILSKCNIQ VHS) of Human FBXW10.

  • 阳性对照
    • Human smooth muscle tissue.

性能

应用

Our Abpromise guarantee covers the use of ab121720 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.
  • 序列相似性Contains 1 F-box domain.
    Contains 7 WD repeats.
  • Information by UniProt
  • 数据库链接
  • 别名
    • F-box and WD-40 domain-containing protein 10 antibody
    • F-box/WD repeat-containing protein 10 antibody
    • FBW10_HUMAN antibody
    • FBXW10 antibody
    • Ubiquitin ligase-specificity factor antibody
    see all

Anti-FBXW10 antibody 图像

  • Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus and nucleoli. Recommended concentration of ab121720 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab121720 at 1/125 dilution staining FBXW10 in Paraffin-embedded Human Smooth muscle tissue by Immunohistochemistry.

Anti-FBXW10 antibody (ab121720)参考文献

ab121720 has not yet been referenced specifically in any publications.

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