概述

  • 产品名称Anti-FBXO7抗体
    参阅全部 FBXO7 一抗
  • 描述
    小鼠单克隆抗体to FBXO7
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: AVCRDLFTAS NDPLLWRFLY LRDFRDNTVR VQDTDWKELY RKRHIQRKES PKGRFVMLLP SSTHTIPFYP NPLHPRPFPS SRLPPGIIGG EYDQRPTLP, corresponding to amino acids 357-456 of Human FBXO7

性能

应用

Our Abpromise guarantee covers the use of ab57037 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.
    • 通路Protein modification; protein ubiquitination.
    • 疾病相关Defects in FBXO7 are the cause of Parkinson disease type 15 (PARK15) [MIM:260300]; also known as parkinsonian-pyramidal syndrome. A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia.
    • 序列相似性Contains 1 F-box domain.
    • 细胞定位Cytoplasm. Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • F box only protein 7 antibody
      • F box protein 7 antibody
      • F-box only protein 7 antibody
      • FBX antibody
      • FBX07 antibody
      • FBX7 antibody
      • FBX7_HUMAN antibody
      • Fbxo7 antibody
      • PARK15 antibody
      • PKPS antibody
      see all

    Anti-FBXO7 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57037 FBXO7 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-FBXO7 antibody (ab57037)参考文献

    ab57037 has not yet been referenced specifically in any publications.

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