概述

  • 产品名称Anti-FbxO6抗体
    参阅全部 FbxO6 一抗
  • 描述
    兔多克隆抗体to FbxO6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human FbxO6 protein (NP_060908.1).

  • 阳性对照
    • Human kidney tissue lysate; HepG2 cell lysate; FbxO6 transfected 293T cell line lysate

性能

应用

Our Abpromise guarantee covers the use of ab103635 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 34 kDa.

靶标

  • 功能Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 F-box domain.
    Contains 1 FBA (F-box associated) domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • F box protein that recognizes sugar chains 2 antibody
    • F box G domain protein 2 antibody
    • F box only protein 6 antibody
    • F box protein 6 antibody
    • F box protein FBG2 antibody
    • F box protein Fbx6 antibody
    • F box/G domain protein 2 antibody
    • F-box only protein 6 antibody
    • F-box protein that recognizes sugar chains 2 antibody
    • F-box/G-domain protein 2 antibody
    • FBG 2 antibody
    • FBG2 antibody
    • FBS 2 antibody
    • FBS2 antibody
    • FBX 6 antibody
    • FBX6 antibody
    • FBX6_HUMAN antibody
    • FBXO 6 antibody
    • FBXO6 antibody
    • OTTHUMP00000002267 antibody
    see all

Anti-FbxO6 antibody 图像

  • Anti-FbxO6 antibody (ab103635) at 1/500 dilution + Human kidney tissue lysate at 50 µg

    Predicted band size : 34 kDa
  • Anti-FbxO6 antibody (ab103635) at 1/500 dilution + HepG2 cell lysate at 50 µg

    Predicted band size : 34 kDa
  • All lanes : Anti-FbxO6 antibody (ab103635) at 1/500 dilution

    Lane 1 : FbxO6 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 34 kDa

Anti-FbxO6 antibody (ab103635)参考文献

ab103635 has not yet been referenced specifically in any publications.

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