概述

  • 产品名称Anti-FBXO31抗体
    参阅全部 FBXO31 一抗
  • 描述
    兔多克隆抗体to FBXO31
  • 经测试应用适用于: WB, ICC/IFmore details
    不适用于: IP
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region within the amino acids 489-539 of Human FBXO31, NP_079011.3

  • 阳性对照
    • Whole cell lysate from 293T and mouse NIH3T3 cells.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab86137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/5000. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa).
ICC/IF Use at an assay dependent concentration. PubMed: 24936062
  • 应用说明Is unsuitable for IP.
  • 靶标

    • 功能Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
    • 组织特异性Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.
    • 通路Protein modification; protein ubiquitination.
    • 序列相似性Belongs to the FBXO31 family.
      Contains 1 F-box domain.
    • 发展阶段Expression is cell-cycle regulated, and peaks at late G2 to early G1 phase (at protein level).
    • 翻译后修饰Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DKFZp434B027 antibody
      • DKFZp434J1815 antibody
      • F box only protein 31 antibody
      • F box protein 31 antibody
      • F-box only protein 31 antibody
      • FBX14 antibody
      • FBX31 antibody
      • FBX31_HUMAN antibody
      • FBXO14 antibody
      • Fbxo31 antibody
      • FLJ22477 antibody
      • MGC15419 antibody
      • MGC9527 antibody
      • pp2386 antibody
      • Putative breast cancer tumor suppressor antibody
      • SCF ubiquitin ligase specificity factor antibody
      see all

    Anti-FBXO31 antibody 图像

    • All lanes : Anti-FBXO31 antibody (ab86137) at 0.4 µg/ml

      Lane 1 : Whole cell lysate from 293T cells
      Lane 2 : Whole cell lysate from mouse NIH3T3 cells

      Lysates/proteins at 50 µg per lane.


      Predicted band size : 61 kDa
      Observed band size : 61 kDa


      Exposure time : 30 seconds

    Anti-FBXO31 antibody (ab86137)参考文献

    This product has been referenced in:
    • Liu J  et al. F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6). J Biol Chem 289:21508-18 (2014). ICC/IF ; Human . Read more (PubMed: 24936062) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab86137.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"