功能Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
组织特异性Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.
通路Protein modification; protein ubiquitination.
序列相似性Belongs to the FBXO31 family. Contains 1 F-box domain.
发展阶段Expression is cell-cycle regulated, and peaks at late G2 to early G1 phase (at protein level).
翻译后修饰Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.