概述

  • 产品名称Anti-FBXO11抗体
    参阅全部 FBXO11 一抗
  • 描述
    小鼠单克隆抗体to FBXO11
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: KAVSRGQCLY KISSYTSYPM HDFYRCHTCN TTDRNAICVN CIKKCHQGHD VEFIRHDRFF CDCGAGTLSN PCTLAGEPTH DTDTLYDSAP PIESNTLQHN , corresponding to amino acids 744-844 of Human FBXO11

性能

应用

Our Abpromise guarantee covers the use of ab57812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53.
    • 组织特异性Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
    • 通路Protein modification; protein ubiquitination.
    • 序列相似性Contains 1 F-box domain.
      Contains 19 PbH1 repeats.
      Contains 1 UBR-type zinc finger.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • F box protein 11 antibody
      • F-box only protein 11 antibody
      • FBX11 antibody
      • FBX11_HUMAN antibody
      • Fbxo11 antibody
      • PRMT9 antibody
      • Protein arginine N methyltransferase 9 antibody
      • Ubiquitin protein ligase E3 component n recognin 6 antibody
      • UBR6 antibody
      • UG063H01 antibody
      • VIT-1 antibody
      • VIT1 antibody
      • Vitiligo associated protein VIT 1 antibody
      • Vitiligo-associated protein 1 antibody
      see all

    Anti-FBXO11 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57812 FBXO11 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-FBXO11 antibody (ab57812)参考文献

    ab57812 has not yet been referenced specifically in any publications.

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