概述

  • 产品名称Anti-FBXO11抗体
    参阅全部 FBXO11 一抗
  • 描述
    兔多克隆抗体to FBXO11
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Horse, Chicken, Guinea pig, Cat, Dog, Human, Drosophila melanogaster, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 726-775 (RRNKIHDGRD GGICIFNGGR GLLEENDIFR NAQAGVLIST NSHPVLRKNR) of Mouse FBXO11 (NP_001074503).

  • 阳性对照
    • Mouse small intestine lysate.

性能

应用

Our Abpromise guarantee covers the use of ab125349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 104 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53.
  • 组织特异性Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 F-box domain.
    Contains 19 PbH1 repeats.
    Contains 1 UBR-type zinc finger.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • F box protein 11 antibody
    • F-box only protein 11 antibody
    • FBX11 antibody
    • FBX11_HUMAN antibody
    • Fbxo11 antibody
    • PRMT9 antibody
    • Protein arginine N methyltransferase 9 antibody
    • Ubiquitin protein ligase E3 component n recognin 6 antibody
    • UBR6 antibody
    • UG063H01 antibody
    • VIT-1 antibody
    • VIT1 antibody
    • Vitiligo associated protein VIT 1 antibody
    • Vitiligo-associated protein 1 antibody
    see all

Anti-FBXO11 antibody 图像

  • Anti-FBXO11 antibody (ab125349) at 1 µg/ml + Mouse small intestine lysate at 10 µg

    Secondary
    Goat anti-Rabbit IgG HRP

    Predicted band size : 104 kDa

Anti-FBXO11 antibody (ab125349)参考文献

ab125349 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab125349.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"