概述

  • 产品名称
  • 描述
    兔多克隆抗体to FBXO11
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Horse, Chicken, Guinea pig, Cat, Dog, Human, Drosophila melanogaster, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 726-775 (RRNKIHDGRD GGICIFNGGR GLLEENDIFR NAQAGVLIST NSHPVLRKNR) of Mouse FBXO11 (NP_001074503).

  • 阳性对照
    • Mouse small intestine lysate.

性能

应用

Our Abpromise guarantee covers the use of ab125349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 104 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53.
  • 组织特异性
    Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Contains 1 F-box domain.
    Contains 19 PbH1 repeats.
    Contains 1 UBR-type zinc finger.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • F box only protein 11 antibody
    • F box protein 11 antibody
    • F-box only protein 11 antibody
    • FBX11 antibody
    • FBX11_HUMAN antibody
    • Fbxo11 antibody
    • PRMT9 antibody
    • Protein arginine N methyltransferase 9 antibody
    • Ubiquitin protein ligase E3 component n recognin 6 antibody
    • UBR6 antibody
    • UG063H01 antibody
    • VIT 1 antibody
    • VIT-1 antibody
    • VIT1 antibody
    • Vitiligo associated protein 1 antibody
    • Vitiligo associated protein VIT 1 antibody
    • Vitiligo-associated protein 1 antibody
    see all

图片

  • Anti-FBXO11 antibody (ab125349) at 1 µg/ml + Mouse small intestine lysate at 10 µg

    Secondary
    Goat anti-Rabbit IgG HRP

    Predicted band size : 104 kDa

实验方案

文献

ab125349 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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