Anti-FBXO11抗体(ab110965)

概述

• 产品名称
  Anti-FBXO11抗体
  参阅全部 FBXO11 一抗
• 描述
  兔多克隆抗体to FBXO11
• 经测试应用
  适用于: WB, ELISA, IHC-Pmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat
• 免疫原

  Synthetic peptide, derived from an internal sequence of FBXO11 (UniProt ID: Q86XK2).

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
• 存储溶液
  Constituent: Whole serum
• 纯度
  Whole antiserum
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteasome / Ubiquitin
  • Ubiquitin E3 Enzymes
  • SCF Complex E3 Ligase

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53.
• 组织特异性
  Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
• 通路
  Protein modification; protein ubiquitination.
• 序列相似性
  Contains 1 F-box domain.
  Contains 19 PbH1 repeats.
  Contains 1 UBR-type zinc finger.
• 细胞定位
  Nucleus.

• Target information above from: UniProt accession Q86XK2 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 80204 Human
  • Entrez Gene: 225055 Mouse
  • Entrez Gene: 301674 Rat
  • Omim: 607871 Human
  • SwissProt: Q86XK2 Human
  • SwissProt: Q7TPD1 Mouse
  • SwissProt: Q7TSL3 Rat
  • Unigene: 352677 Human

  • Unigene: 386857 Mouse
  • Unigene: 36585 Rat

  see all
• 别名
  • F box only protein 11 antibody
  • F box protein 11 antibody
  • F-box only protein 11 antibody

  • FBX11 antibody
  • FBX11_HUMAN antibody
  • Fbxo11 antibody
  • PRMT9 antibody
  • Protein arginine N methyltransferase 9 antibody
  • Ubiquitin protein ligase E3 component n recognin 6 antibody
  • UBR6 antibody
  • UG063H01 antibody
  • VIT 1 antibody
  • VIT-1 antibody
  • VIT1 antibody
  • Vitiligo associated protein 1 antibody
  • Vitiligo associated protein VIT 1 antibody
  • Vitiligo-associated protein 1 antibody

  see all

实验方案

• Western blot protocols
• Immunohistochemistry protocols