概述

  • 产品名称Anti-FBXL3抗体
    参阅全部 FBXL3 一抗
  • 描述
    小鼠单克隆抗体to FBXL3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: MKRGGRDSDR NSSEEGTAEK SKKLRTTNEH SQTCDWGNLL QDIILQVFKY LPLLDRAHAS QVCRNWNQVF HMPDLWRCFE FELNQPATSY LKATHPELIK , corresponding to amino acids 1-101 of Human FBXL3 (NP_036290) with a 26kDa enzyme tag

  • 阳性对照
    • HeLa cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab77200 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).

靶标

  • 功能Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation.
  • 组织特异性Widely expressed.
  • 序列相似性Contains 1 F-box domain.
    Contains 7 LRR (leucine-rich) repeats.
  • 细胞定位Nucleus. Cytoplasm. Predominantly nuclear.
  • Information by UniProt
  • 数据库链接
  • 别名
    • F box and leucine rich repeat protein 3 antibody
    • F box and leucine rich repeat protein 3A antibody
    • F box protein Fbl3a antibody
    • F-box and leucine-rich repeat protein 3A antibody
    • F-box/LRR-repeat protein 3 antibody
    • F-box/LRR-repeat protein 3A antibody
    • FBL3 antibody
    • FBL3A antibody
    • Fbxl3 antibody
    • FBXL3_HUMAN antibody
    • FBXL3A antibody
    see all

Anti-FBXL3 antibody 图像

  • Anti-FBXL3 antibody (ab77200) at 1/500 dilution + HeLa cell lysate at 25 µg

    Secondary
    HRP-conjugated goat anti-mouse IgG at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 49 kDa
    Observed band size : 49 kDa
  • Anti-FBXL3 antibody (ab77200) at 1/500 dilution + immunogen (37.11 KDa) at 0.1 µg

    Secondary
    HRP-conjugated goat anti-mouse IgG at 1/5000 dilution
    Developed using the ECL technique

    Predicted band size : 49 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)

Anti-FBXL3 antibody (ab77200)参考文献

ab77200 has not yet been referenced specifically in any publications.

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