概述

  • 产品名称Anti-FBXL20抗体
    参阅全部 FBXL20 一抗
  • 描述
    兔多克隆抗体to FBXL20
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    An 18 amino acid peptide near the carboxy terminus of human FBXL20.

  • 阳性对照
    • A20 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab67232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 44, 48 kDa (predicted molecular weight: 44 , 48 kDa).
IHC-P Use a concentration of 2.5 µg/ml.

靶标

  • 相关性FBXL20 is a member of the F-box protein family, which are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. FBXL20 is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. FBXL20 has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. FBXL20 is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
  • 细胞定位Cytoplasmic
  • 数据库链接
  • 别名
    • F box and leucine rich repeat protein 20 antibody
    • F box/LRR repeat protein 2 like antibody
    • F box/LRR repeat protein 20 antibody
    • Fbl2 antibody
    • Fbl20 antibody
    • MGC15482 antibody
    • SCR antibody
    • SCRAPPER antibody
    see all

Anti-FBXL20 antibody 图像

  • Lane 1 : Anti-FBXL20 antibody (ab67232) at 0.5 µg/ml
    Lane 2 : Anti-FBXL20 antibody (ab67232) at 1 µg/ml

    Lane 1 : A20 cell lysate
    Lane 2 : A20 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 44 , 48 kDa
    Observed band size : 44 and 48 kDa (why is the actual band size different from the predicted?)
  • ab67232 at 2.5 µg/ml staining FBXL20 in human brain tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

Anti-FBXL20 antibody (ab67232)参考文献

ab67232 has not yet been referenced specifically in any publications.

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