概述

  • 产品名称Anti-FBXL20抗体
    参阅全部 FBXL20 一抗
  • 描述
    兔多克隆抗体to FBXL20
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 110-159 (RTFAQNCRNI EVLNLNGCTK TTDATCTSLS KFCSKLRHLD LASCTSITNM) of Human FBXL20 (NP_116264).

  • 阳性对照
    • Human fetal brain lysate

性能

应用

Our Abpromise guarantee covers the use of ab113803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 相关性FBXL20 is a member of the F-box protein family, which are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. FBXL20 is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. FBXL20 has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. FBXL20 is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
  • 细胞定位Cytoplasmic
  • 数据库链接
  • 别名
    • F box and leucine rich repeat protein 20 antibody
    • F box/LRR repeat protein 2 like antibody
    • F box/LRR repeat protein 20 antibody
    • Fbl2 antibody
    • Fbl20 antibody
    • MGC15482 antibody
    • SCR antibody
    • SCRAPPER antibody
    see all

Anti-FBXL20 antibody 图像

  • Anti-FBXL20 antibody (ab113803) at 1 µg/ml + Human fetal brain lysate at 10 µg

    Predicted band size : 48 kDa

Anti-FBXL20 antibody (ab113803)参考文献

ab113803 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113803.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"