概述

  • 产品名称Anti-FBXL11抗体
    参阅全部 FBXL11 一抗
  • 描述
    兔多克隆抗体to FBXL11
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Gorilla, Orangutan, Bat
  • 免疫原

    Synthetic peptide corresponding to a region between residue 825 and 875 (SSANLRHSPR VLVQHCPART PQRGDEEGLG GEEEEEEEEE EEDDSAEEGG A) of Human FBXL11 (NP_036440.1).

  • 阳性对照
    • Human Anaplastic Thyroid Carcinoma, Breast Carcinoma, Lung Adenocarcinoma, Ovarian Carcinoma, Skin Basal Cell Carcinoma and Stomach Adenocarcinoma

性能

应用

Our Abpromise guarantee covers the use of ab99242 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

靶标

  • 功能Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
  • 组织特异性Widely expressed, with highest levels in brain, testis and ovary, followed by lung.
  • 序列相似性Belongs to the JHDM1 histone demethylase family.
    Contains 1 CXXC-type zinc finger.
    Contains 1 F-box domain.
    Contains 1 JmjC domain.
    Contains 6 LRR (leucine-rich) repeats.
    Contains 1 PHD-type zinc finger.
  • 结构域The JmjC domain mediates demethylation activity and is required for satellite silencing.
    The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA is methylated.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus > nucleoplasm. Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.
  • Information by UniProt
  • 数据库链接
  • 别名
    • [Histone-H3]-lysine-36 demethylase 1A antibody
    • CXXC-type zinc finger protein 8 antibody
    • CXXC8 antibody
    • F box / LRR repeat protein 11 antibody
    • F box and leucine rich repeat protein 11 antibody
    • F box protein FBL7 antibody
    • F-box and leucine-rich repeat protein 11 antibody
    • F-box protein FBL7 antibody
    • F-box protein Lilina antibody
    • F-box/LRR-repeat protein 11 antibody
    • FBL11 antibody
    • FBL7 antibody
    • FBXL11 antibody
    • JHDM1A antibody
    • JmjC domain-containing histone demethylation protein 1A antibody
    • Jumonji C domain containing histone demethylase 1A antibody
    • kdm2a antibody
    • KDM2A_HUMAN antibody
    • LILINA antibody
    • Lysine (K) specific demethylase 2A antibody
    • Lysine-specific demethylase 2A antibody
    see all

Anti-FBXL11 antibody 图像

  • ab99242, at 1/250 dilution, staining FBXL11 in formalin-fixed paraffin-embedded Human skin basal cell carcinoma by Immunohistochemistry using DAB staining.
  • ab99242, at 1/250 dilution, staining FBXL11 in formalin-fixed paraffin-embedded Human breast carcinoma by Immunohistochemistry using DAB staining.

Anti-FBXL11 antibody (ab99242)参考文献

ab99242 has not yet been referenced specifically in any publications.

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