概述

  • 产品名称Anti-FBP17抗体
    参阅全部 FBP17 一抗
  • 描述
    山羊多克隆抗体to FBP17
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Zebrafish
  • 免疫原

    Synthetic peptide:

    KQLESSKRRFERDC

    , corresponding to amino acids 132 - 145 of Human FBP17.

  • 阳性对照
    • Human Testis lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab23934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明Peptide ELISA: 1/32000.
    WB: Use at a concentration of 0.25 - 2.0 µg/ml. Predicted molecular weight: 70 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
    • 组织特异性Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
    • 疾病相关Note=A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.
    • 序列相似性Belongs to the FNBP1 family.
      Contains 1 FCH domain.
      Contains 1 REM (Hr1) repeat.
      Contains 1 SH3 domain.
    • 细胞定位Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FBP1 antibody
      • FBP17 antibody
      • Fnbp1 antibody
      • FNBP1_HUMAN antibody
      • Formin binding protein 1 antibody
      • Formin binding protein 17 antibody
      • Formin-binding protein 1 antibody
      • Formin-binding protein 17 antibody
      • hFBP17 antibody
      • KIAA0554 antibody
      • MGC126804 antibody
      see all

    Anti-FBP17 antibody 图像

    • Anti-FBP17 antibody (ab23934) at 0.25 µg/ml + Human Testis lysate (RIPA buffer, 35µg total protein per lane).

      Predicted band size : 70 kDa
      Observed band size : 70 kDa

    Anti-FBP17 antibody (ab23934)参考文献

    ab23934 has not yet been referenced specifically in any publications.

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