Anti-FBP17抗体(ab113961)

概述

  • 产品名称Anti-FBP17抗体
    参阅全部 FBP17 一抗
  • 描述
    山羊多克隆抗体to FBP17
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide,

    KQLESSKRRFERDC

    , corresponding to internal sequence amino acids 132-145 of Human FBP17

  • 阳性对照
    • Human Small Intestine and Human Tonsil tissue Human testis lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C.
  • 存储溶液pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab113961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.25 - 2 µg/ml. Predicted molecular weight: 71 kDa.
ELISA 1/32000.
IHC-P Use a concentration of 3.75 µg/ml.

靶标

  • 功能May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
  • 组织特异性Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
  • 疾病相关Note=A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.
  • 序列相似性Belongs to the FNBP1 family.
    Contains 1 FCH domain.
    Contains 1 REM (Hr1) repeat.
    Contains 1 SH3 domain.
  • 细胞定位Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FBP1 antibody
    • FBP17 antibody
    • Fnbp1 antibody
    • FNBP1_HUMAN antibody
    • Formin binding protein 1 antibody
    • Formin binding protein 17 antibody
    • Formin-binding protein 1 antibody
    • Formin-binding protein 17 antibody
    • hFBP17 antibody
    • KIAA0554 antibody
    • MGC126804 antibody
    see all

Anti-FBP17 antibody 图像

  • Immunohistochemical staining of Human Small Intestine using ab113961 at 3.75µg/ml
  • Immunohistochemical staining of Human Tonsil using ab113961 at 3.75µg/ml
  • Anti-FBP17 antibody (ab113961) at 0.25 µg/ml + Human testis lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 71 kDa

Anti-FBP17 antibody (ab113961)参考文献

ab113961 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"