Anti-FBLIM1抗体(ab112590)

概述

  • 产品名称Anti-FBLIM1抗体
    参阅全部 FBLIM1 一抗
  • 描述
    兔多克隆抗体to FBLIM1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide between 301-331 amino acids from the C-terminal region of Human FBLIM1 (NP_001019387.1 , NP_001019386.1 , NP_060026.2).

  • 阳性对照
    • A549 cell line lysate

性能

应用

Our Abpromise guarantee covers the use of ab112590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 41 kDa.

靶标

  • 功能Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly.
  • 组织特异性Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.
  • 序列相似性Contains 3 LIM zinc-binding domains.
  • 细胞定位Cytoplasm > cell cortex. Cell junction > focal adhesion. Cytoplasm > cytoskeleton. Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with PLEKHC1. Isoform 2 is localized at actin stress fibers.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2410043F08Rik antibody
    • Cal antibody
    • CSX associated LIM antibody
    • DKFZp434G171 antibody
    • FBLI1_HUMAN antibody
    • FBLIM 1 antibody
    • Fblim1 antibody
    • FBLP 1 antibody
    • FBLP-1 antibody
    • FBLP1 antibody
    • Filamin binding LIM protein 1 antibody
    • Filamin-binding LIM protein 1 antibody
    • Gt10 antibody
    • MGC105665 antibody
    • MIG2 interacting protein; antibody
    • MIG2-interacting protein antibody
    • Migfilin antibody
    • Mitogen inducible 2 interacting protein antibody
    • Mitogen-inducible 2-interacting protein antibody
    • OTTHUMP00000003118 antibody
    • OTTHUMP00000003119 antibody
    • OTTHUMP00000003120 antibody
    • OTTMUSP00000011062 antibody
    • OTTMUSP00000011063 antibody
    • RP11-169K16.5 antibody
    • RP23-291H3.1 antibody
    see all

Anti-FBLIM1 antibody 图像

  • Anti-FBLIM1 antibody (ab112590) at 1/100 dilution + A549 cell line lysate at 35 µg

    Predicted band size : 41 kDa

Anti-FBLIM1 antibody (ab112590)参考文献

ab112590 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Mouse Cell (Mouse Embryonic Fibroblast (MEF))
Specification Mouse Embryonic Fibroblast (MEF)
Fixative Paraformaldehyde
Permeabilization Yes - triton
Username

Abcam user community

Verified customer

提交于 Nov 16 2011

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (HeLa cell line ( cervical cancer))
Specification HeLa cell line ( cervical cancer)
Fixative Paraformaldehyde
Permeabilization Yes - triton
Username

Abcam user community

Verified customer

提交于 Nov 16 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"