Anti-FAT抗体[Fat-1] (ab20163)

概述

  • 产品名称Anti-FAT抗体[Fat-1]
    参阅全部 FAT 一抗
  • 描述
    小鼠单克隆抗体[Fat-1] to FAT
  • 经测试应用适用于: WB, ICC/IF, ELISAmore details
  • 种属反应性
    与反应: Drosophila melanogaster
    预测可用于: Rat, Chimpanzee
  • 免疫原

    Cytoplasmic domain of drosphila FAT 1

  • 阳性对照
    • Wild type imaginal discs from third instar larva

性能

应用

Our Abpromise guarantee covers the use of ab20163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ICC/IF
ELISA
  • 应用说明ELISA: Use at an assay dependent dilution.
    IF: Use at an assay dependent dilution.
    WB: Use 3-8% gradient gels to visualise the FAT protein and wet transfer. Predicted molecular weight: 506 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
    • 组织特异性Expressed in many epithelial and some endothelial and smooth muscle cells.
    • 序列相似性Contains 33 cadherin domains.
      Contains 5 EGF-like domains.
      Contains 1 laminin G-like domain.
    • 结构域A PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation.
    • 翻译后修饰Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.
    • 细胞定位Cell membrane. Nucleus. Cytoplasm > perinuclear region.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Cadherin family member 7 antibody
      • Cadherin family member 7 precursor antibody
      • Cadherin ME5 antibody
      • Cadherin related tumor suppressor antibody
      • Cadherin related tumor suppressor homolog antibody
      • Cadherin related tumor suppressor homolog precursor antibody
      • Cadherin related tumor suppressor homolog precursor (FAT protein homolog) antibody
      • Cadherin-related tumor suppressor homolog antibody
      • CDHF 7 antibody
      • CDHF7 antibody
      • FAT 1 antibody
      • FAT tumor suppressor 1 antibody
      • FAT tumor suppressor homolog 1 antibody
      • FAT1 antibody
      • FAT1_HUMAN antibody
      • hFat 1 antibody
      • hFAT antibody
      • hFat1 antibody
      • Homolog of Drosophila FAT protein antibody
      • Homolog of Drosophila FAT protein precursor antibody
      • Homolog of Drosophila tumor suppressor FAT precursor antibody
      • ME 5 antibody
      • ME5 antibody
      • nuclear form antibody
      • Protein fat homolog antibody
      • Protocadherin Fat 1 antibody
      see all

    Anti-FAT antibody [Fat-1] (ab20163)参考文献

    ab20163 has not yet been referenced specifically in any publications.

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    Thank you for contacting us. This product has not been tested in human. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"