Anti-FAT/FAT1抗体(ab198892)
Key features and details
- Rabbit polyclonal to FAT/FAT1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-FAT/FAT1抗体
参阅全部 FAT/FAT1 一抗 -
描述
兔多克隆抗体to FAT/FAT1 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human FAT/FAT1 (internal sequence). Gene Accession: NP_005236.
Database link: Q14517 -
阳性对照
- Human thyroid cancer tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab198892于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/50 - 1/200.
|
说明 |
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IHC-P
1/50 - 1/200. |
靶标
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功能
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. -
组织特异性
Expressed in many epithelial and some endothelial and smooth muscle cells. -
序列相似性
Contains 33 cadherin domains.
Contains 5 EGF-like domains.
Contains 1 laminin G-like domain. -
结构域
A PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation. -
翻译后修饰
Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus. -
细胞定位
Cell membrane. Nucleus. Cytoplasm > perinuclear region. - Information by UniProt
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数据库链接
- Entrez Gene: 2195 Human
- Omim: 600976 Human
- SwissProt: Q14517 Human
- Unigene: 481371 Human
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别名
- Cadherin family member 7 antibody
- Cadherin family member 7 precursor antibody
- Cadherin ME5 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab198892 被引用在 1 文献中.
- Lu Y et al. FAT1 and PTPN14 Regulate the Malignant Progression and Chemotherapy Resistance of Esophageal Cancer through the Hippo Signaling Pathway. Anal Cell Pathol (Amst) 2021:9290372 (2021). PubMed: 34712552