功能Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
序列相似性Belongs to the fascin family.
结构域Composed of four beta-trefoil domains.
翻译后修饰Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.