概述

  • 产品名称Anti-Fascin 2抗体
    参阅全部 Fascin 2 一抗
  • 描述
    山羊多克隆抗体to Fascin 2
  • 特异性ab78599 is expected to recognize both reported isoforms (NP_001070650.1 and NP_036550.1) of Fascin 2.
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Cow, Dog, Human
  • 免疫原

    Synthetic peptide:

    CHHRGSNQLDTNR

    , corresponding to internal sequence amino acids of Human Fascin 2 (NP_001070650.1 and NP_036550.1)

  • 阳性对照
    • Mouch cochlea.

性能

应用

Our Abpromise guarantee covers the use of ab78599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Preliminary experiments gave bands at approx 75kDa and 22kDa in Mouse Eye lysates after 0.05µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

靶标

  • 功能Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
  • 组织特异性Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.
  • 疾病相关Defects in FSCN2 are the cause of retinitis pigmentosa type 30 (RP30) [MIM:607921]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP30 inheritance is autosomal dominant.
  • 序列相似性Belongs to the fascin family.
  • 细胞定位Cytoplasm > cytoskeleton. Cell projection > stereocilium.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Fascin homolog 2, actin bundling protein, retinal Strongylocentrotus purpuratus antibody
    • Fascin Strongylocentrotus purpuratus homolog 2 actin bundling protein, retinal antibody
    • Fascin-2 antibody
    • FSCN2 antibody
    • FSCN2_HUMAN antibody
    • Retinal fascin antibody
    • RFSN antibody
    • RP30 antibody
    see all

Anti-Fascin 2 antibody (ab78599)参考文献

ab78599 has not yet been referenced specifically in any publications.

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