概述

  • 产品名称Anti-Fas Ligand抗体[H11]
    参阅全部 Fas Ligand 一抗
  • 描述
    大鼠单克隆抗体[H11] to Fas Ligand
  • 经测试应用适用于: ICC, Flow Cyt, WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Cat, Dog, Human
  • 免疫原

    Synthetic peptide:

    RGQSCNNQPLNHKVYMRNSKYPEDL

    , corresponding to amino acids 196-220 of Mouse Fas Ligand.

性能

应用

Our Abpromise guarantee covers the use of ab16104 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab18450-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
WB Use a concentration of 1 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 31 kDa).

靶标

  • 功能Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
  • 疾病相关Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
  • 序列相似性Belongs to the tumor necrosis factor family.
  • 翻译后修饰N-glycosylated.
    The soluble form derives from the membrane form by proteolytic processing.
  • 细胞定位Cell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALPS1B antibody
    • Apoptosis (APO 1) antigen ligand 1 antibody
    • Apoptosis antigen ligand 1 antibody
    • Apoptosis antigen ligand antibody
    • APT1LG1 antibody
    • APTL antibody
    • CD178 antibody
    • CD178 antigen antibody
    • CD95 ligand antibody
    • CD95-L antibody
    • CD95L antibody
    • CD95L protein antibody
    • Fas antigen ligand antibody
    • Fas L antibody
    • Fas ligand (TNF superfamily member 6) antibody
    • Fas ligand antibody
    • FASL antibody
    • Fasl Fas ligand (TNF superfamily member 6) antibody
    • FASLG antibody
    • Generalized lymphoproliferative disease antibody
    • Gld antibody
    • soluble form antibody
    • TNFL6_HUMAN antibody
    • TNFSF6 antibody
    • Tumor necrosis factor (ligand) superfamily member 6 antibody
    • Tumor necrosis factor ligand superfamily member 6 antibody
    see all

Anti-Fas Ligand antibody [H11] 图像



  • Predicted band size : 31 kDa


    ab16104 detecting Fas Ligand in 293T cells transfected with a Fas Ligand expression plasmid (right panel) or mock-transfected cells (left panel) by Western blot.

Anti-Fas Ligand antibody [H11] (ab16104)参考文献

This product has been referenced in:
  • Hunt ME & Brown DR Role of sialidase in Mycoplasma alligatoris-induced pulmonary fibroblast apoptosis. Vet Microbiol 121:73-82 (2007). Read more (PubMed: 17276629) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab16104.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"