Anti-Fas抗体,prediluted (ab27091)

概述

  • 产品名称
    Anti-Fas抗体,prediluted
    参阅全部 Fas 一抗
  • 描述
    兔多克隆抗体to Fas,prediluted
  • 宿主
    Rabbit
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human Fas (C terminal).

  • 阳性对照
    • Small intestine.

性能

应用

Our Abpromise guarantee covers the use of ab27091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明
    IHC-P: Use neat for 10 minutes at room temperature. Antigen retrieval is not essential but boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 minutes followed by cooling at RT for 20 minutes may optimise staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
    • 组织特异性
      Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
    • 疾病相关
      Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
    • 序列相似性
      Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.
    • 结构域
      Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
    • 细胞定位
      Secreted and Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ALPS 1A antibody
      • ALPS1A antibody
      • APO 1 antibody
      • Apo 1 antigen antibody
      • APO 1 cell surface antigen antibody
      • Apo-1 antigen antibody
      • APO1 antibody
      • Apo1 antigen antibody
      • APO1 cell surface antigen antibody
      • Apoptosis antigen 1 antibody
      • Apoptosis mediating surface antigen FAS antibody
      • Apoptosis-mediating surface antigen FAS antibody
      • APT 1 antibody
      • APT1 antibody
      • CD 95 antibody
      • CD 95 antigen antibody
      • CD95 antibody
      • CD95 antigen antibody
      • Delta Fas antibody
      • Delta Fas/APO 1/CD95 antibody
      • Delta Fas/APO1/CD95 antibody
      • Fas (TNF receptor superfamily, member 6) antibody
      • FAS 1 antibody
      • FAS 827dupA antibody
      • Fas AMA antibody
      • Fas antibody
      • FAS Antigen antibody
      • Fas cell surface death receptor antibody
      • FAS1 antibody
      • FASLG receptor antibody
      • FASTM antibody
      • sFAS antibody
      • Surface antigen APO1 antibody
      • TNF receptor superfamily, member 6 antibody
      • TNFRSF 6 antibody
      • TNFRSF6 antibody
      • TNR6_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 6 antibody
      see all

    图片

    • Human small intestine stained with Anti-CD95 antibody

    文献

    ab27091 has not yet been referenced specifically in any publications.

    客户评价及客户问答

    There are currently no Customer reviews or Questions for ab27091.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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