Anti-Fas抗体[LT95] (ab1088)


  • 产品名称Anti-Fas抗体[LT95]
    参阅全部 Fas 一抗
  • 描述
    小鼠单克隆抗体[LT95] to Fas
  • 特异性Human Fas (CD95/APO-1).
  • 经测试应用适用于: IHC-P, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Tissue, cells or virus corresponding to Human Fas.

  • 阳性对照
    • Reacts strongly with IM9 and HUT-78 cell lines. Reacts moderately with Raji, Ramos, U266, Jurkat, BJAB and ML-1 cell lines. Reacts weakly with KG1a, U937, KM3 and TF-1 cell lines. Does not react with K562 and THP-1 cell lines.



Our Abpromise guarantee covers the use of ab1088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration.


  • 功能Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
  • 组织特异性Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
  • 疾病相关Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
  • 序列相似性Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • 结构域Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALPS 1A antibody
    • ALPS1A antibody
    • APO 1 antibody
    • Apo 1 antigen antibody
    • APO 1 cell surface antigen antibody
    • Apo-1 antigen antibody
    • APO1 antibody
    • Apo1 antigen antibody
    • APO1 cell surface antigen antibody
    • Apoptosis antigen 1 antibody
    • Apoptosis mediating surface antigen FAS antibody
    • Apoptosis-mediating surface antigen FAS antibody
    • APT 1 antibody
    • APT1 antibody
    • CD 95 antibody
    • CD 95 antigen antibody
    • CD95 antibody
    • CD95 antigen antibody
    • Delta Fas antibody
    • Delta Fas/APO 1/CD95 antibody
    • Delta Fas/APO1/CD95 antibody
    • Fas (TNF receptor superfamily, member 6) antibody
    • FAS 1 antibody
    • FAS 827dupA antibody
    • Fas AMA antibody
    • Fas antibody
    • FAS Antigen antibody
    • Fas cell surface death receptor antibody
    • FAS1 antibody
    • FASLG receptor antibody
    • FASTM antibody
    • sFAS antibody
    • Surface antigen APO1 antibody
    • TNF receptor superfamily, member 6 antibody
    • TNFRSF 6 antibody
    • TNFRSF6 antibody
    • TNR6_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 6 antibody
    see all

Anti-Fas antibody [LT95] 图像

  • Flow cytometry analysis of Fas expression on the surface of various hematopoietic (A- Jurkat, B- Ramos, C- CEM and D- MOLT-4) cell lines with purified ab1088. Goat anti-mouse IgG was used as the secondart antibody.


    Red – Isotype mouse IgG1 control staining

    Black – standard anti-Fas monoclonal antibody

    Green – Fas (LT95) staining with ab1088

Anti-Fas antibody [LT95] (ab1088)参考文献

ab1088 has not yet been referenced specifically in any publications.

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ab1088 does not induce Fas mediated apoptosis in susceptible cells. For the other four antibodies you specify, ab1121, ab1122, ab8283, and ab10040, I'm afraid that none of them have been tested to see whether they induce apoptosis to human Fas-expressi...

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