Anti-FANCI抗体(ab15346)

概述

  • 产品名称Anti-FANCI抗体
    参阅全部 FANCI 一抗
  • 描述
    兔多克隆抗体to FANCI
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    This information is considered to be commercially sensitive.

性能

应用

Our Abpromise guarantee covers the use of ab15346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2500 - 1/10000. Detects a band of approximately 155 kDa.

靶标

  • 功能Required for maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination and in the repair of DNA cross-links. Participates in S phase and G2 phase checkpoint activation upon DNA damage. Promotes FANCD2 ubiquitination and recruitment to DNA repair sites.
  • 疾病相关Defects in FANCI are a cause of Fanconi anemia complementation group I (FANCI) [MIM:609053]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
  • 结构域The C-terminal 30 residues are probably required for function in DNA repair.
  • 翻译后修饰Monoubiquitinated on Lys-523 during S phase and upon genotoxic stress. Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the FANCA-FANCB-FANCC-FANCE-FANCF-FANCG-FANCM complex. Ubiquitination is required for binding to chromatin, DNA repair, and normal cell cycle progression.
    Phosphorylated in response to DNA damage by ATM and/or ATR.
  • 细胞定位Nucleus. Concentrates in nuclear foci upon genotoxic stress.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FANCI antibody
    • FANCI gene antibody
    • FANCI_HUMAN antibody
    • Fanconi anemia group I protein antibody
    • Fanconi anemia, complementation group I antibody
    • FLJ10719 antibody
    • FLJ14658 antibody
    • KIAA1794 antibody
    • Protein FACI antibody
    • Protein FANCI antibody
    see all

Anti-FANCI antibody 图像

  • Rabbit polyclonal to KIAA1794 (ab15346) at 1/5000.

    Lane 1: 5µg HeLa cell nuclear extract
    Lane 2: 20 µg HeLa cell nuclear extract

    Detection: chemiluminescence with an exposure time of 15 minutes.

Anti-FANCI antibody (ab15346)参考文献

ab15346 has not yet been referenced specifically in any publications.

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Thank you for your interest in our antibodies. We do not provide samples of our antibodies as under our Abpromise we guarantee our antibodies to work as stated on the data sheet. In the case of ab15344, ab74332 and ab15346as they are only guaranteed to...

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