概述

  • 产品名称Anti-FANCB抗体
    参阅全部 FANCB 一抗
  • 描述
    小鼠多克隆抗体to FANCB
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein (Human), (NP_001018123).

  • 阳性对照
    • FANCB transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab72810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 98 kDa.

靶标

  • 功能DNA repair protein required for FANCD2 ubiquitination.
  • 疾病相关Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB) [MIM:300514]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
    Defects in FANCB are the cause of X-linked VACTERL-H (XVACTERL-H) [MIM:314390]; also known as X-linked VACTERL association with hydrocephalus syndrome. VACTERL is an acronym for vertebral anomalies, anal atresia, cardiac malformations, tracheoesophageal fistula, renal anomalies (urethral atresia with hydronephrosis), and limb anomalies (hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb). Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FA2 antibody
    • FAAP90 antibody
    • FAAP95 antibody
    • FAB antibody
    • FACB antibody
    • Fancb antibody
    • FANCB_HUMAN antibody
    • Fanconi anemia associated polypeptide of 95 kDa antibody
    • Fanconi anemia group B protein antibody
    • Fanconi anemia, complementation group B antibody
    • Fanconi anemia-associated polypeptide of 95 kDa antibody
    • Protein FACB antibody
    see all

Anti-FANCB antibody 图像

  • All lanes : Anti-FANCB antibody (ab72810) at 1/500 dilution

    Lane 1 : FANCB transfected 293T cell lysate
    Lane 2 : Untransfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 98 kDa
    Observed band size : 105 kDa (why is the actual band size different from the predicted?)

Anti-FANCB antibody (ab72810)参考文献

ab72810 has not yet been referenced specifically in any publications.

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