Anti-FAM126A抗体(ab98144)
Key features and details
- Rabbit polyclonal to FAM126A
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-FAM126A抗体 -
描述
兔多克隆抗体to FAM126A -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Recombinant protein fragment corresponding to a region within amino acids 178 and 416 of Human FAM126A (NP_115970).
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阳性对照
- 293T, A431, H1299 ,HeLa, HepG2, MOLT4 and Raji cell lysates
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab98144于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 58 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 58 kDa. |
靶标
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功能
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway. -
组织特异性
Widely expressed. Highest levels in heart, brain, placenta, spleen and testis. -
疾病相关
Leukodystrophy, hypomyelinating, 5 -
序列相似性
Belongs to the FAM126 family. -
细胞定位
Cytoplasm, cytosol. Cell membrane. Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex. - Information by UniProt
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数据库链接
- Entrez Gene: 84668 Human
- Entrez Gene: 84652 Mouse
- Omim: 610531 Human
- SwissProt: Q9BYI3 Human
- SwissProt: Q6P9N1 Mouse
- Unigene: 85603 Human
- Unigene: 304976 Mouse
- Unigene: 486278 Mouse
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别名
- Down regulated by Ctnnb1 a antibody
- Down regulated by CTNNB1 protein A antibody
- Down-regulated by CTNNB1 protein A antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab98144 尚未被引用在任何文献中。