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Synthetic peptide (Human) derived from the region of human Focal Adhesion Kinase that contains tyrosine 861. The sequence is conserved in human, mouse, rat, chicken and frog.
Focal Adhesion Kinase is a 125 kDa non-receptor protein tyrosine kinase that is a substrate for Src and a key element in growth factor and integrin signalling. Focal Adhesion Kinase plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. Tyr861 of Focal Adhesion Kinase is a major Src phosphorylation site that allows Focal Adhesion Kinase to bind to integrins and is also involved in cancer.
Our Abpromise guarantee covers the use of ab4804 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-Fr||Use at an assay dependent concentration.|
|WB||Use at an assay dependent concentration. Predicted molecular weight: 125 kDa.Can be blocked with FAK (phospho Y861) peptide (ab5304). Can be blocked with FAK peptide - phospho Y861 (phospho and non-phospho pair) or CEF whole cell lysate, positive / negative for Focal Adhesion Kinase (pair).|
|ICC/IF||Use at an assay dependent concentration. PubMed: 21525268|
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