概述

  • 产品名称Anti-FAIM3抗体
    参阅全部 FAIM3 一抗
  • 描述
    兔多克隆抗体to FAIM3
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to 13 amino acids near the C terminal of Human FAIM3.

  • 阳性对照
    • Human kidney tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab115211 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
  • 组织特异性Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat cells, CemT4 cells, MolT-4 cells, HB11.19 cells, and Reh cells. No expression detected in nonhematopoietic cell lines, including HepG2 cells, 293 cells and Hela cells.
  • 序列相似性Contains 1 Ig-like (immunoglobulin-like) domain.
  • 结构域The Ig-like domain is required for the anti-apoptotic ability.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Faim3 antibody
    • FAIM3_HUMAN antibody
    • Fas apoptotic inhibitory molecule 3 antibody
    • Fc mu receptor antibody
    • FCMR antibody
    • IgM Fc receptor antibody
    • Immunoglobulin mu Fc receptor antibody
    • Regulator of Fas induced apoptosis antibody
    • Regulator of Fas-induced apoptosis Toso antibody
    • TOSO antibody
    see all

Anti-FAIM3 antibody 图像

  • ab115211, at 5 ug/ml, staining FAIM3 in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-FAIM3 antibody (ab115211)参考文献

ab115211 has not yet been referenced specifically in any publications.

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