概述

描述

  • 性质
    Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab54083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    Blocking - Blocking peptide for Anti-FADD antibody (ab24533)

  • 纯度
    > 90 % SDS-PAGE.

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • FADD
    • FADD protein
    • FADD_HUMAN
    • Fas (TNFRSF6) associated via death domain
    • Fas associated via death domain
    • Fas associating death domain containing protein
    • Fas associating protein
    • Fas associating protein with death domain
    • Fas TNFRSF6 associated via death domain
    • FAS-associated death domain protein
    • FAS-associating death domain-containing protein
    • GIG 3
    • GIG3
    • Growth inhibiting gene 3 protein
    • Growth-inhibiting gene 3 protein
    • H sapiens mRNA for mediator of receptor induced toxicity
    • Mediator of receptor induced toxicity
    • MGC8528
    • MORT 1
    • MORT1
    • Protein FADD
    see all
  • 功能
    Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
  • 组织特异性
    Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
  • 序列相似性
    Contains 1 death domain.
    Contains 1 DED (death effector) domain.
  • 结构域
    Contains a death domain involved in the binding of the corresponding domain within Fas receptor.
  • Information by UniProt

文献

ab54083 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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