Anti-Factor XIII/XIIIa抗体(ab45000)

概述

  • 产品名称Anti-Factor XIII/XIIIa抗体
    参阅全部 Factor XIII/XIIIa 一抗
  • 描述
    兔多克隆抗体to Factor XIII/XIIIa
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein corresponding to A-subunit of human coagulation Factor XIII.

  • 阳性对照
    • Capillary hemangioma, dermatofibroma and placenta.

性能

应用

Our Abpromise guarantee covers the use of ab45000 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 160 kDa (un-reduced dimer) or 80kDa (reduced monomer).
IHC-P 1/2000.

靶标

  • 相关性Factor XIII is a beta globulin found in plasma and is composed of two subunits. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Factor XIII A is the catalytic subunit and is a dimmer of molecular weight 160kDa. The B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIII A, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
  • 细胞定位Cytoplasmic in most tissues, but also secreted in the blood plasma
  • 数据库链接
  • 别名
    • Coagulation factor XIII A chain antibody
    • Coagulation factor XIII A chain precursor antibody
    • Coagulation factor XIII A polypeptide antibody
    • Coagulation factor XIII A1 polypeptide antibody
    • Coagulation factor XIII A1 subunit antibody
    • Coagulation factor XIIIa antibody
    • F13A antibody
    • F13A1 antibody
    • Factor XIIIA antibody
    • FXIIIA antibody
    • Protein glutamine gamma glutamyltransferase A chain antibody
    • TGase antibody
    • Transglutaminase A chain antibody
    see all

Anti-Factor XIII/XIIIa antibody (ab45000)参考文献

ab45000 has not yet been referenced specifically in any publications.

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