概述

  • 产品名称
    Anti-Factor XIa抗体
    参阅全部 Factor XIa 一抗
  • 描述
    兔多克隆抗体to Factor XIa
  • 经测试应用
    适用于: WB, RIA, ELISAmore details
  • 种属反应性
    与反应: Cow
  • 免疫原

    Full length native protein Bovine FXIa purified from bovine plasma

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, PBS, pH 7.5
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab100878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 70 kDa.
RIA Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.

靶标

  • 功能
    Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
  • 组织特异性
    Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
  • 疾病相关
    Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
  • 序列相似性
    Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
    Contains 4 apple domains.
    Contains 1 peptidase S1 domain.
  • 翻译后修饰
    Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • coagulation factor XI antibody
    • Coagulation factor XIa light chain antibody
    • F11 antibody
    • FA11_HUMAN antibody
    • FXI antibody
    • MGC141891 antibody
    • Plasma thromboplastin antecedent antibody
    • Platelet coagulation factor XI antibody
    • PTA antibody
    see all

实验方案

文献

ab100878 has not yet been referenced specifically in any publications.

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