Anti-Factor XI抗体[MM0193-7C38] (ab89335)

概述

• 产品名称Anti-Factor XI抗体[MM0193-7C38]
  参阅全部 Factor XI 一抗
• 描述
  小鼠单克隆抗体[MM0193-7C38] to Factor XI
• 特异性ab89335 detects Factor XI.
• 经测试应用适用于: WB, Neutralisingmore details
• 种属反应性
  与反应: Human
  
• 免疫原

  Recombinant full length Human Factor XI protein.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液Preservative: None
  Constituents: PBS
• Concentration information loading...
• 纯度Protein G purified
• 纯化说明The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution.
• 克隆单克隆
• 克隆编号MM0193-7C38
• 同种型IgG2
• 研究领域
  • Cardiovascular
  • Blood
  • Serum Proteins

  • Cardiovascular
  • Blood
  • Platelets

  • Cardiovascular
  • Blood
  • Coagulation
  • Intrinsic

相关产品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

应用

靶标

• 功能Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
• 组织特异性Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
• 疾病相关Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
• 序列相似性Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
  Contains 4 apple domains.
  Contains 1 peptidase S1 domain.
• 翻译后修饰Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
• 细胞定位Secreted.

• Target information above from: UniProt accession P03951 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 2160 Human
  • Omim: 264900 Human
  • SwissProt: P03951 Human
  • Unigene: 1430 Human
• 别名
  • Coagulation factor XI antibody
  • Coagulation factor XIa light chain antibody
  • F11 antibody

  • FA11_HUMAN antibody
  • FXI antibody
  • MGC141891 antibody
  • Plasma thromboplastin antecedent antibody
  • PTA antibody

  see all