Anti-Factor XI抗体[MM0193-7C38] (ab89335)

概述

• 产品名称
  Anti-Factor XI抗体[MM0193-7C38]
  参阅全部 Factor XI 一抗
• 描述
  小鼠单克隆抗体[MM0193-7C38] to Factor XI
• 特异性
  ab89335 detects Factor XI.
• 经测试应用
  适用于: WB, Neutralisingmore details
• 种属反应性
  与反应: Human
  
• 免疫原

  Recombinant full length Human Factor XI protein.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液
  Preservative: None
  Constituents: PBS
• Concentration information loading...
• 纯度
  Protein G purified
• 纯化说明
  The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution.
• 克隆
  单克隆
• 克隆编号
  MM0193-7C38
• 同种型
  IgG2
• 研究领域
  • Cardiovascular
  • Blood
  • Serum Proteins

  • Cardiovascular
  • Blood
  • Platelets

  • Cardiovascular
  • Blood
  • Coagulation
  • Intrinsic

相关产品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

应用

靶标

• 功能
  Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
• 组织特异性
  Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
• 疾病相关
  Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
• 序列相似性
  Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
  Contains 4 apple domains.
  Contains 1 peptidase S1 domain.
• 翻译后修饰
  Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
• 细胞定位
  Secreted.

• Target information above from: UniProt accession P03951 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 2160 Human
  • Omim: 264900 Human
  • SwissProt: P03951 Human
  • Unigene: 1430 Human
• 别名
  • Coagulation factor XI antibody
  • Coagulation factor XIa light chain antibody
  • F11 antibody

  • FA11_HUMAN antibody
  • FXI antibody
  • MGC141891 antibody
  • Plasma thromboplastin antecedent antibody
  • PTA antibody

  see all

实验方案

• Western blot protocols