概述
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产品名称Anti-Factor XI抗体(Biotin)
参阅全部 Factor XI 一抗 -
描述兔多克隆抗体to Factor XI (Biotin)
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宿主Rabbit
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偶联物Biotin
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经测试应用适用于: WB, ELISA, RIAmore details
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种属反应性与反应: Human
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免疫原
Human Factor XI purified from Human plasma.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, pH 7.5 -
Concentration information loading... -
纯度Protein G purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab105847 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | Use at an assay dependent dilution. Predicted molecular weight: 70 kDa. | |
| ELISA | Use at an assay dependent dilution. | |
| RIA | Use at an assay dependent dilution. |
靶标
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功能Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
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组织特异性Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
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疾病相关Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
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序列相似性Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain. -
翻译后修饰Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
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细胞定位Secreted.
- Information by UniProt
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数据库链接
- Entrez Gene: 2160 Human
- Omim: 264900 Human
- SwissProt: P03951 Human
- Unigene: 1430 Human
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别名
- Coagulation factor XI antibody
- Coagulation factor XIa light chain antibody
- F11 antibody
see all
文献
ab105847 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"