Anti-Factor Xa Heavy Chain抗体(ab75180)


  • 产品名称Anti-Factor Xa Heavy Chain抗体
    参阅全部 Factor Xa Heavy Chain 一抗
  • 描述
    兔多克隆抗体to Factor Xa Heavy Chain
  • 特异性Detects endogenous levels of fragment of Factor Xa resulting from cleavage adjacent to Ile235
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from human Factor Xa heavy chain.

  • 阳性对照
    • Extracts from rat liver cells



Our Abpromise guarantee covers the use of ab75180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明ELISA: 1/20000.
    WB: 1/500 - 1/1000. Predicted molecular weight: 55 kDa (uncleaved precursor).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
    • 组织特异性Plasma; synthesized in the liver.
    • 疾病相关Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
    • 序列相似性Belongs to the peptidase S1 family.
      Contains 2 EGF-like domains.
      Contains 1 Gla (gamma-carboxy-glutamate) domain.
      Contains 1 peptidase S1 domain.
    • 翻译后修饰The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
      N- and O-glycosylated.
      The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Activated factor Xa heavy chain antibody
      • Coagulation factor X antibody
      • F10 antibody
      • FA10_HUMAN antibody
      • Factor X antibody
      • Factor X deficiency antibody
      • Factor Xa antibody
      • FX antibody
      • FXA antibody
      • Prothrombinase antibody
      • Stuart factor antibody
      • Stuart Prower factor antibody
      • Stuart-Prower factor antibody
      • Stuart-Prower factor deficiency antibody
      see all

    Anti-Factor Xa Heavy Chain antibody 图像

    • All lanes : Anti-Factor Xa Heavy Chain antibody (ab75180) at 1/500 dilution

      Lane 1 : extracts from rat liver cells
      Lane 2 : extracts from rat liver cells with immunizing peptide at 5 µg

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 55 kDa
      Observed band size : 30 kDa (why is the actual band size different from the predicted?)

    Anti-Factor Xa Heavy Chain antibody (ab75180)参考文献

    ab75180 has not yet been referenced specifically in any publications.

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    The immunogen of ab75180 corresponds to the amino acid sequence between 235-488 (Swiss-port No. P00742). This sequence corresponds to the factor Xa chain of coagulation factor X. This ab will not recognize unclea...

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