Anti-Factor X抗体(ab61389)

概述

  • 产品名称Anti-Factor X抗体
    参阅全部 Factor X 一抗
  • 描述
    大鼠单克隆抗体to Factor X
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Full length native purified Mouse Factor X

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 50% (v/v)Glycerol/water
  • Concentration information loading...
  • 纯度Ion Exchange Chromatography
  • 纯化说明Salt fractionation followed by gel filtration and ion exchange chromatography.
  • 克隆单克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab61389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 55 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
  • 组织特异性Plasma; synthesized in the liver.
  • 疾病相关Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
  • 序列相似性Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • 翻译后修饰The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
    N- and O-glycosylated.
    The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 形式Cleaved into the following 3 chains: 1. Factor X light chain 2. Factor X heavy chain 3. Activated factor Xa heavy chain
  • 别名
    • Activated factor Xa heavy chain antibody
    • Coagulation factor X antibody
    • F10 antibody
    • FA10_HUMAN antibody
    • factor Xa antibody
    • FX antibody
    • FXA antibody
    • Prothrombinase antibody
    • Stuart factor antibody
    • Stuart Prower factor antibody
    • Stuart-Prower factor antibody
    see all

Anti-Factor X antibody (ab61389)参考文献

ab61389 has not yet been referenced specifically in any publications.

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Smearing could come from too much albumin and IgGs in the sample (these are inherent to plasma samples and dominate over other proteins in the plasma). Thus, removing those beforehand could help as well. There are columns commercially available specifi...

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