Anti-Factor VII抗体(ab104564)

概述

  • 产品名称
    Anti-Factor VII抗体
    参阅全部 Factor VII 一抗
  • 描述
    羊多克隆抗体to Factor VII
  • 特异性
    ab104564 is specific for Factor VII as determined by immunodiffusion. Identity was established with purified Factor VII.
  • 经测试应用
    适用于: IP, ELISA, IHC-P, Neutralisingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human Factor VII purified from plasma.

  • 阳性对照
    • Human Liver tissue

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: 50% Glycerol, HEPES, pH 7.4
  • Concentration information loading...
  • 纯度
    Ammonium Sulphate Precipitation
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab104564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Neutralising Use at an assay dependent dilution.

靶标

  • 功能
    Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
  • 组织特异性
    Plasma.
  • 疾病相关
    Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:227500]. FA7D is a rare hereditary hemorrhagic disease. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Numerous subjects are completely asymptomatic despite a very low F7 level.
  • 序列相似性
    Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • 翻译后修饰
    The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • coagulation factor VII (serum prothrombin conversion accelerator) antibody
    • Coagulation factor VII antibody
    • Eptacog alfa antibody
    • F7 antibody
    • FA7_HUMAN antibody
    • Factor VII antibody
    • Factor VII heavy chain antibody
    • Factor VII light chain antibody
    • FVII coagulation protein antibody
    • OTTHUMP00000018733 antibody
    • OTTHUMP00000018734 antibody
    • Proconvertin antibody
    • Serum prothrombin conversion accelerator antibody
    • SPCA antibody
    see all

Anti-Factor VII antibody 图像

  • ab104564, at 5 ug/ml, staining Factor VII in formalin-fixed, paraffin-embedded Human Liver by Immunohistochemistry, using a biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Factor VII antibody (ab104564)参考文献

ab104564 has not yet been referenced specifically in any publications.

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