概述

  • 产品名称Anti-Factor Va抗体
  • 描述
    羊多克隆抗体to Factor Va
  • 特异性This antibody recognizes Human Factor Va.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Native, purified human Factor Va

  • 常规说明Concentration 5-10mg/ml (lot specific).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 50% Glycerol/ Water
  • Concentration information loading...
  • 纯度Ion Exchange Chromatography
  • 纯化说明Salt fractionation followed by ion exchange chromatography on DEAE sepharose.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab81460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 168 kDa.

靶标

  • 相关性Factor Va is a cofactor for the serine protease factor Xa, and in the presence of calcium ions they collectively assemble on a phospholipid surface to form the prothrombinase complex. The prothrombinase complex is responsible for the rapid conversion of prothrombin to thrombin. Factor Va is derived from the pro-cofactor, factor V, upon limited proteolysis by alpha-thrombin. The thrombin cleavage of factor V liberates two heavily glycosylated activation peptides from the central portion of the molecule which have no cofactor function. Factor Va is comprised of an NH2-terminal derived heavy chain (MW 94kDa) and a COOH-terminal derived light chain (MW 74kDa) which remain associated in the presence of calcium ions. The cofactor binds to phospholipid (cell membrane) surfaces and effectively serves as a receptor for membrane bound factor Xa. Complete assembly of the prothrombinase complex (factor Xa, factor Va, phospholipid, and calcium) results in a 300,000-fold increase in the rate of prothrombin conversion relative to the rate observed with factor Xa alone. The interaction between factor Va and factor Xa is mediated by both the heavy and light chain of factor Va, while the binding of prothrombin to factor Va is mediated solely by the heavy chain.
  • 细胞定位Cell Membrane and Plasma membrane
  • 数据库链接
  • 别名
    • Activated protein c cofactor antibody
    • Coagulation factor V (proaccelerin, labile factor) antibody
    • Coagulation factor V antibody
    • F5 antibody
    • Factor V Leiden antibody
    • FVL antibody
    • PCCF antibody
    see all

Anti-Factor Va antibody (ab81460)参考文献

ab81460 has not yet been referenced specifically in any publications.

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