Anti-Factor V Light Chain抗体[CBC-MOR101] (ab1009)

概述

  • 产品名称Anti-Factor V Light Chain抗体[CBC-MOR101]
    参阅全部 Factor V Light Chain 一抗
  • 描述
    小鼠单克隆抗体[CBC-MOR101] to Factor V Light Chain
  • 特异性This antibody reacts with the light chain (mw ~74,000) of human Factor V.
  • 经测试应用适用于: ELISA, IHC-P, IHC-Fr, Neutralisingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Purified human Factor V.

  • 表位This antibody recognizes an epitope (exact sequence unknown) in the F1F2 polypeptide of human Factor V and activated Factor V (Factor Va).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液PBS, pH7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号CBC-MOR101
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab1009 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
IHC-P
IHC-Fr
Neutralising
  • 应用说明This antibody neutralizes Factor V activity. KD = 0.3 x 10-10mol/L.
    This antibody can also be used for autoradiography.
  • 靶标

    • 相关性Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin. Factor Va is composed of a heavy chain and a light chain, noncovalently bound. The interaction between the two chains is calcium-dependent. Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Defects in F5 are the cause of Owren parahemophilia which is an hemorrhagic diastesis. Defects in F5 are the cause of resistance to activated protein C (APCR). APCR is a form of thrombophilia. The APCR mutation is found in about 5% of the population which suggest that a slight thrombotic tendency may confer some advantage in fetal implantation.
    • 细胞定位Secreted
    • 数据库链接
    • 别名
      • Activated protein C cofactor antibody
      • Coagulation factor V antibody
      • Coagulation factor V heavy chain antibody
      • Coagulation factor V light chain antibody
      • F5 antibody
      see all

    Anti-Factor V Light Chain antibody [CBC-MOR101] (ab1009)参考文献

    This product has been referenced in:

    See 1 Publication for this product

    Product Wall

    Thank you for your enquiry. These antibodies are two different clones. Ab1009 - Mouse monoclonal [CBC-MOR101] to Factor V Light Chain - recognizes an epitope (exact sequence unknown) in the F1F2 polypeptide of human Factor V and actiVated Factor V (Fac...

    Read More

    Thank you for your enquiry. For ab21037, the antibody was tested against purified Human Factor V and against human plasma in ELISA and Western blot. The characterization of ab20951, MAb to Factor V (Clone 701), was described in the following publish...

    Read More

    Anti-Factor V staining is seen in the cytoplasm of platelets and megakaryo-cytes.

    Human bone marrow smears can be used. Marrows are smeared, air-dried, fixed immediately in methanol:acetone (1:9) and stored frozen at -20 C until used.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"