Anti-Factor V Light Chain抗体(ab61413)

概述

  • 产品名称Anti-Factor V Light Chain抗体
    参阅全部 Factor V Light Chain 一抗
  • 描述
    小鼠单克隆抗体to Factor V Light Chain
  • 特异性Recognises human factor V and Va, light chain (fragment E, 74,000) of factor Va
  • 经测试应用适用于: WB, ELISA, RIAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native purified Human Factor V Light Chain

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 50% Glycerol, Water
  • Concentration information loading...
  • 纯度Ion Exchange Chromatography
  • 纯化说明Salt fractionation followed by gel filtration and ion exchange chromatography
  • 克隆单克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab61413 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 252 kDa.
ELISA Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

靶标

  • 相关性Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin. Factor Va is composed of a heavy chain and a light chain, noncovalently bound. The interaction between the two chains is calcium-dependent. Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Defects in F5 are the cause of Owren parahemophilia which is an hemorrhagic diastesis. Defects in F5 are the cause of resistance to activated protein C (APCR). APCR is a form of thrombophilia. The APCR mutation is found in about 5% of the population which suggest that a slight thrombotic tendency may confer some advantage in fetal implantation.
  • 细胞定位Secreted
  • 数据库链接
  • 别名
    • Activated protein C cofactor antibody
    • Coagulation factor V antibody
    • Coagulation factor V heavy chain antibody
    • Coagulation factor V light chain antibody
    • F5 antibody
    see all

Anti-Factor V Light Chain antibody (ab61413)参考文献

ab61413 has not yet been referenced specifically in any publications.

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The clone number for ab61348 is AHV-5146 and for ab61413 it is AHV-5108.

I will send you the clone nunmber for ab1015 soon.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"