概述

  • 产品名称Anti-Factor V抗体[EPR5191]
    参阅全部 Factor V 一抗
  • 描述
    兔单克隆抗体[EPR5191] to Factor V
  • 经测试应用适用于: Flow Cyt, WBmore details
    不适用于: ICC,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues in the light chain of Human Factor V

  • 阳性对照
    • Human plasma and platelet lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab108614 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration. PubMed: 27492853
WB 1/1000 - 1/10000. Predicted molecular weight: 252 kDa.
  • 应用说明Is unsuitable for ICC,IHC-P or IP.
  • 靶标

    • 功能Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
    • 组织特异性Plasma.
    • 疾病相关Factor V deficiency
      Thrombophilia due to activated protein C resistance
      Budd-Chiari syndrome
      Ischemic stroke
      Pregnancy loss, recurrent, 1
    • 序列相似性Belongs to the multicopper oxidase family.
      Contains 3 F5/8 type A domains.
      Contains 2 F5/8 type C domains.
      Contains 6 plastocyanin-like domains.
    • 结构域Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
    • 翻译后修饰Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
      Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
      Activated protein C inactivates factor V and factor Va by proteolytic degradation.
      Phosphorylation sites are present in the extracellular medium.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Activated protein C cofactor antibody
      • APC cofactor antibody
      • coagulation factor V (proaccelerin, labile factor) antibody
      • Coagulation factor V antibody
      • coagulation factor V jinjiang A2 domain antibody
      • Coagulation factor V light chain antibody
      • F5 antibody
      • FA5_HUMAN antibody
      • Factor V Leiden antibody
      • FactorV antibody
      • FVL antibody
      • Labile factor antibody
      • PCCF antibody
      • Proaccelerin antibody
      • proaccelerin, labile factor antibody
      • Protein C cofactor antibody
      • RPRGL1 antibody
      • THPH2 antibody
      see all

    Anti-Factor V antibody [EPR5191] 图像

    • All lanes : Anti-Factor V antibody [EPR5191] (ab108614) at 1/1000 dilution

      Lane 1 : Human plasma lysate
      Lane 2 : Human platelet lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 252 kDa

    Anti-Factor V antibody [EPR5191] (ab108614)参考文献

    This product has been referenced in:
    • Kaliberov SA  et al. Retargeted adenoviruses for radiation-guided gene delivery. Cancer Gene Ther N/A:N/A (2016). Flow Cyt ; Human . Read more (PubMed: 27492853) »

    See 1 Publication for this product

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